Study on the Expression Patterns of Inner Root Sheath-Specific Genes in Tan Sheep Hair Follicle During Different Developmental Stages

July 2024 in “ Gene ”

An Shi, Jiangjiang Lv, Qing Ma, Zhanfa Liu, Lina Ma, Junhan Zhou, Jinzhong Tao

inner root sheath hair follicle RT-qPCR skin samples KRT71 KRT72 TCHH wool crimp gene expression developmental stages root sheath PCR skin keratin 71 keratin 72 trichohyalin

TLDR IRS-specific genes in Tan sheep hair follicles peak at birth and may affect wool crimp.

This study analyzed the expression patterns of inner root sheath (IRS) specific genes in Tan sheep hair follicles at various developmental stages. Skin samples were collected from male Tan sheep at five stages: 85 and 120 days of fetal development, and 0, 35, and 60 days after birth. The results showed that IRS-specific genes, particularly KRT71, KRT72, and TCHH, had the highest expression levels at birth (D0), which aligns with the wool crimp pattern observed in Tan sheep. This suggests that these genes may influence wool curling by affecting the morphology of the IRS.

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