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Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro

58 citations , June 1987 in “Archives of Dermatological Research”

This study found that epidermal and fibroblast growth factors increased proliferation of human hair bulb papilla cells and root sheath fibroblasts in vitro, while hydrocortisone decreased it and minoxidil had no effect.

research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-mediated Root Sheath Disruption in Advance of Overt Hair Loss

37 citations , November 2003 in “Veterinary pathology”

This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.

research Enhanced in vitro hair growth at the air-liquid interface: minoxidil preserves the root sheath in cultured whisker follicles

12 citations , July 1993 in “In Vitro Cellular & Developmental Biology - Animal”

Minoxidil enhances hair growth and preserves the root sheath in cultured follicles.

research Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro

9 citations , March 1987 in “British Journal of Dermatology”

This study found that epidermal growth factor and fibroblast growth factor accelerated proliferation of human hair bulb papilla cells and root sheath fibroblasts cultured in vitro.

research Effects of testosterone, dihydrotestosterone and estradiol on the growth behavior of cultured hair bulb papilla cells and root sheath fibroblasts

5 citations , January 1989

This study found that testosterone and dihydrotestosterone inhibit the growth rates of hair bulb papilla cells and root sheath fibroblasts, especially at higher doses, while estradiol was ineffective.

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community Why is minoxidil the “regrowth stimulant” and finasteride “the maintenance”, when official studies show more growth on finasteride ?

in Research/Science 46 upvotes 6 months ago

Finasteride is more effective for long-term hair maintenance by addressing the root cause of hair loss, while minoxidil acts as a growth stimulant with faster visible results. Combining both treatments is optimal, with oral minoxidil often showing better results for some individuals.

community Protective effects of taurine on human hair follicle grown in vitro. - PubMed

4 upvotes 7 years ago

Taurine promotes hair survival and protects hair follicles. Users discuss trying topical taurine for hair growth.

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

5 upvotes 4 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community You may not have the enzyme for topical minoxidil to work - a rarely talked about impact

100 upvotes 11 months ago

Some people may not respond to topical minoxidil due to low SULT1A1 enzyme activity, but oral minoxidil can be effective. Tretinoin may enhance minoxidil's effectiveness, and some users prefer oral minoxidil despite side effects.

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