Sex Hormones and Antiandrogens Influence Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles In Vitro
January 1993
testosterone dihydrotestosterone antiandrogens anagen hair bulb papillae interfollicular dermal fibroblasts keratinocytes papilla cells outer root sheath keratinocytes androgens mesenchymal cells epithelial cells hair follicle DHT hair bulb dermal fibroblasts hair cells root sheath cells hair growth cells
TLDR Testosterone and dihydrotestosterone can slow down the growth of certain hair follicle cells.
In a study from 1993, researchers investigated the effects of testosterone, dihydrotestosterone, and antiandrogens on the growth of cells related to human hair follicles. They cultured cells from the anagen hair bulb papillae, interfollicular dermal fibroblasts, and keratinocytes for 14 days, and then exposed them to various concentrations of these hormones. The study found that testosterone and dihydrotestosterone at a concentration of 345 nM significantly reduced the proliferation of papilla cells when compared to dermal fibroblasts and outer root sheath keratinocytes. The results suggest that these androgens negatively affect the growth behavior of the mesenchymal and epithelial cells within the hair follicle.