Studysummary This study reports that variation in the ovine TCHH gene may influence wool fibre curvature, with specific gene variants affecting the mean fibre curvature in sheep.
The study investigated the variation in the ovine trichohyalin (TCHH) gene and its association with wool curvature in sheep. Using PCR-single stranded conformational polymorphism analysis, three sequence variants (A, B, and C) were identified in 210 sheep, with frequencies of 59.0%, 36.9%, and 4.1%, respectively. Two single nucleotide polymorphisms (SNPs) were found, one in intron 2 and a non-synonymous SNP in exon 3, which resulted in an amino acid change. The study found that progeny inheriting variant A produced wool with lower mean fibre curvature compared to those inheriting variant B, suggesting that variation in the TCHH gene affects wool curvature. No effects on other wool traits were observed.
42 citations
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January 2017 in “Genes” This study observed that genetic variation in the ovine KRTAP22-1 gene is linked to increased wool yield and decreased fiber curvature in sheep, indicating its potential use in breeding programs.
98 citations
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May 2016 in “Genes” This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.
234 citations
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November 2009 in “American journal of human genetics” This study identified genetic variants in the Trichohyalin gene that account for approximately 6% of the variance in hair morphology among Australians of European descent.
108 citations
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October 2003 in “Journal of biological chemistry/The Journal of biological chemistry” This study documents that trichohyalin acts as a multi-functional cross-bridging protein in the inner root sheath of mouse hair follicles, enhancing mechanical strength by linking keratin filaments to the cell envelope.
27 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” 161 citations
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June 1993 in “Journal of Biological Chemistry” This study suggests that human trichohyalin may function as a flexible rod linking keratin intermediate filaments and as a scaffold protein in hair follicle and epidermis cell envelopes.
72 citations
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May 1993 in “The Journal of Cell Biology” This study detailed the structure and amino acid composition of sheep trichohyalin, noting its presence in various tissues and suggesting a possible functional role beyond structural support in hair follicles.
