Dynamic Changes of Genomic Methylation Profiles at Different Growth Stages in Chinese Tan Sheep

November 2021 in “ Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology ”

Yufang Liu, Qiao Xu, Xiaolong Kang, Kejun Wang, Jve Wang, Dengzhen Feng, Ying Bai, Meiying Fang

DNA methylation differentially methylated genes MAPK signaling pathway WNT signaling pathway hair follicle morphogenesis KRT71 CD44 ROR2 ZDHHC13

TLDR DNA methylation changes in Tan sheep affect growth and fur traits.

The study investigated the dynamic changes in DNA methylation profiles in Chinese Tan sheep at 1 month, 24 months, and 48 months of age using 11 skin samples. Researchers identified differentially methylated genes (DMGs) between these stages, with 52, 288, and 236 DMGs found between mon1 and mon24, mon1 and mon48, and mon24 and mon48, respectively. Key genes such as KRT71 and CD44 were highly methylated in mon1, while ROR2 and ZDHHC13 were highly methylated in mon48. The study highlighted the enrichment of DMGs in the MAPK and WNT signaling pathways, which are related to age growth and hair follicle morphogenesis. These findings provided insights into the biological mechanisms underlying growth variations and suggested potential strategies for retaining the economically valuable "nine bends" fur characteristic in Tan sheep.

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