TLDR Genetic variations affecting skin structure play a key role in severe acne.
A genome-wide association study involving 3,823 acne cases and 16,144 controls, followed by a meta-analysis with previous data, identified 20 independent association signals at 15 risk loci, 12 of which were novel. The study implicated variants in WNT10A and SEMA4B, and found that risk alleles at the 1q25 locus increased LAMC2 expression, linked to epidermolysis bullosa. These results suggested that genetic variations affecting skin structure and maintenance, particularly the pilosebaceous unit, played a crucial role in severe acne predisposition.
96 citations,
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May 2010 in “Journal of Cellular Physiology” Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.
197 citations,
June 2009 in “American journal of human genetics” WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Immune cells are essential for early hair and skin development and healing.
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March 2019 in “British Journal of Dermatology” Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.
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May 2021 in “Nature Communications” Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.
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April 2016 in “Journal of Investigative Dermatology” New genes found linked to balding, may help develop future treatments.
130 citations,
March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
