Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep

June 2022 in “ BMC genomics ”

Junlin He, Bi Zhao, Xixia Huang, Xuefeng Fu, Guifen Liu, Yuezhen Tian, Chunli Wu, Jingyi Mao, Jing Liu, Shuangbao Gun, Kechuan Tian

hair follicle development differentially expressed genes DEGs LAMA5 WNT10A BMP7 hair follicle morphogenesis alopecia areata

TLDR Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.

This study analyzed mRNA data from skin tissues of 18 Merino sheep at various embryonic and postnatal stages to identify candidate genes related to hair follicle development. Researchers identified 7,879 differentially expressed genes (DEGs) and 12,623 novel DEGs, revealing complex interactions and stage-specific expression patterns. Key genes such as LAMA5, WNT10A, and BMP7 were identified as crucial for hair follicle morphogenesis. The findings provide a molecular basis for breeding fine wool sheep and offer insights into hair follicle development, which could also inform research on human hair loss and alopecia areata.

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Research cited in this study

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Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep

Research cited in this study

research Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

research TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cells on Hair Follicle Regeneration

research Using WGCNA to Identify Hub Genes of Skin Hair Follicle Development in Fetal Stage of Inner Mongolia Cashmere Goat

research Azelaic Acid Stimulates Catalase Activation and Promotes Hair Growth Through Upregulation of Gli1 and Gli2 mRNA and Shh Protein

research All-Trans-Retinoic Acid Inhibits Mink Hair Follicle Growth by Inhibiting Proliferation and Inducing Apoptosis of Dermal Papilla Cells Through TGF-β2/Smad2/3 Pathway

research PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

research Hair Follicle Differentiation-Specific Keratin Expression in Human Basal Cell Carcinoma

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Expression of Vimentin in Hair Follicle Growth Cycle of Inner Mongolian Cashmere Goats

research A Missense Mutation Within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis

research Laminin α5 in the Keratinocyte Basement Membrane Is Required for Epidermal–Dermal Intercommunication

research Autosomal Recessive Hypotrichosis With Woolly Hair Caused By A Mutation In The Keratin 25 Gene Expressed In Hair Follicles

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research Reduction In Wool Follicles Prior To Birth In Merino Sheep

research Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling

research Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia.

research Localization of Epidermal Growth Factor Immunoreactivity in Sheep Skin During Wool Follicle Development

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