Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep

June 2022 in “ BMC genomics ”

Junlin He, Bi Zhao, Xixia Huang, Xuefeng Fu, Guifen Liu, Yuezhen Tian, Chunli Wu, Jingyi Mao, Jing Liu, Shuangbao Gun, Kechuan Tian

hair follicle development differentially expressed genes DEGs LAMA5 WNT10A BMP7 hair follicle morphogenesis alopecia areata

TLDR Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.

This study analyzed mRNA data from skin tissues of 18 Merino sheep at various embryonic and postnatal stages to identify candidate genes related to hair follicle development. Researchers identified 7,879 differentially expressed genes (DEGs) and 12,623 novel DEGs, revealing complex interactions and stage-specific expression patterns. Key genes such as LAMA5, WNT10A, and BMP7 were identified as crucial for hair follicle morphogenesis. The findings provide a molecular basis for breeding fine wool sheep and offer insights into hair follicle development, which could also inform research on human hair loss and alopecia areata.

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