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GlossaryTrichohyalin (TCHH)

protein in hair follicles aiding keratin filament organization

Trichohyalin is a protein found in hair follicles and the inner root sheath of hair. It plays a crucial role in the structural integrity and strength of hair by helping to organize and cross-link keratin filaments, which are the main structural components of hair.

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research Identification of Trichohyalin-Like 1, an S100 Fused-Type Protein Selectively Expressed in Hair Follicles

27 citations , May 2011 in “Journal of Investigative Dermatology”

TCHHL1 is a protein important for hair growth, found in hair follicles.

research Variation in the Ovine Trichohyalin Gene and Its Association with Wool Curvature

8 citations , December 2017 in “Small Ruminant Research”

Variation in the TCHH gene affects wool curliness in sheep.

research Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans

234 citations , November 2009 in “American journal of human genetics”

Common variants in the Trichohyalin gene are linked to straight hair in Europeans.

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations , November 2016 in “American journal of human genetics”

Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria

41 citations , July 2016 in “Journal of Investigative Dermatology”

Dysplastic nevi have unique gene expressions, making them distinct from common melanocytic nevi.

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