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GlossaryTrichohyalin (TCHH)

protein in hair follicles aiding keratin filament organization

Trichohyalin is a protein found in hair follicles and the inner root sheath of hair. It plays a crucial role in the structural integrity and strength of hair by helping to organize and cross-link keratin filaments, which are the main structural components of hair.

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research Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans

234 citations, November 2009 in “American journal of human genetics”

Common variants in the Trichohyalin gene are linked to straight hair in Europeans.

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations, November 2016 in “American journal of human genetics”

Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research Transcriptome Profile at Different Physiological Stages Reveals Potential Mechanism for Curly Fleece in Chinese Tan Sheep

55 citations, August 2013 in “PloS one”

Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.

research Evaluation of the Predictive Capacity of DNA Variants Associated with Straight Hair in Europeans

36 citations, September 2015 in “Forensic Science International: Genetics”

Certain DNA variants can predict straight hair in Europeans but are not highly specific.

research Study on the Expression Patterns of Inner Root Sheath-Specific Genes in Tan Sheep Hair Follicle During Different Developmental Stages

July 2024 in “Gene”

IRS-specific genes in Tan sheep hair follicles peak at birth and may affect wool crimp.

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