Proteomic Analysis Identifies Differentially Expressed Proteins Participating in Forming Type III Brush Hair in Yangtze River Delta White Goat
January 2015
in “
Genetics and molecular research
”
Type III hair non-Type III hair skin tissues 2-dimensional gel electrophoresis protein spots mass spectrometry fibrinogen beta chain isoform 1 ATP synthase beta subunit succinyl-CoA:3-ketoacid-coenzyme A transferase 1-mitochondrial-like actin-cytoplasmic 1 hair follicle development 2D gel electrophoresis fibrinogen beta chain ATP synthase succinyl-CoA transferase actin
TLDR Researchers found four key proteins that affect the development of a specific hair type in Yangtze River Delta white goats.
In a study conducted on the Yangtze River Delta white goat, researchers aimed to understand the differences between Type III hair and non-Type III hair by analyzing skin tissues. They used 2-dimensional gel electrophoresis technology and identified ten protein spots with at least a 2-fold change in expression. Mass spectrometry and database matching led to the identification of four differentially expressed proteins. Two proteins, fibrinogen beta chain isoform 1 and ATP synthase beta subunit, were found to be upregulated in Type III hair, while the other two, succinyl-CoA:3-ketoacid-coenzyme A transferase 1-mitochondrial-like and actin-cytoplasmic 1, were upregulated in non-Type III hair. These proteins are significant in hair follicle development, and the study's findings contribute to understanding the mechanisms behind the formation of Type III hair in this goat breed.
