Genome-Wide Identification, Characterization, and Expression Analysis of Keratin Genes (KRTs) Family in Yak (Bos Grunniens)

    January 2022 in “ Gene ”
    Qiyu Bao, Xiaolan Zhang, Pengjia Bao, Liang Chen, Xian Guo, Mancai Yin, Min Chen, Ping Yan
    TLDR Scientists found 53 keratin genes in yaks that are important for hair growth and share similarities with those in other animals.
    This study systematically identified and characterized 53 keratin genes (KRTs) in the yak genome, including 23 type I and 30 type II keratins. Bioinformatics analysis revealed conserved domains and multiple phosphorylation sites, with subcellular localization predicted in the nucleus, cytoskeleton, and cytoplasm. The study also demonstrated five distinct expression patterns of KRTs throughout the hair cycle, with Cluster II being the most prominent. Nine hub keratin genes were identified using the WGCNA method, showing strong correlations with hair follicle development and other cellular processes. These findings provide insights into the molecular mechanisms and evolutionary relationships of keratins in yaks.
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