Genome-Wide Identification, Characterization, and Expression Analysis of Keratin Genes (KRTs) Family in Yak (Bos Grunniens)

    January 2022 in “ Gene ”
    Qiyu Bao, Xiaolan Zhang, Pengjia Bao, Liang Chen, Xian Guo, Mancai Yin, Min Chen, Ping Yan
    TLDR Scientists found 53 keratin genes in yaks that are important for hair growth and share similarities with those in other animals.
    This study systematically identified and characterized 53 keratin genes (KRTs) in the yak genome, including 23 type I and 30 type II keratins. Bioinformatics analysis revealed conserved domains and multiple phosphorylation sites, with subcellular localization predicted in the nucleus, cytoskeleton, and cytoplasm. The study also demonstrated five distinct expression patterns of KRTs throughout the hair cycle, with Cluster II being the most prominent. Nine hub keratin genes were identified using the WGCNA method, showing strong correlations with hair follicle development and other cellular processes. These findings provide insights into the molecular mechanisms and evolutionary relationships of keratins in yaks.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    6 / 172 results

      community Keratin microspheres - breakthrough

      in Research/Science  14 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  14 upvotes 5 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community M29 - 4 YEARS on Dutasteride - almost no progress

      in Chat  7 upvotes 2 weeks ago
      The user has been on a comprehensive hair loss treatment regimen for four years, including Dutasteride, topical and oral Minoxidil, and various other treatments, but has seen little progress and is considering a hair transplant. Despite trying multiple therapies, including PRP and exosome injections, the user is still experiencing hair thinning and is hesitant about trying peptides due to potential cancer risks.

    Related Research

    4 / 4 results