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GlossaryKeratin 2 (KRT2)

protein providing structural strength to skin, hair, and nails

Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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research Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells

March 2025 in “International Journal of Molecular Sciences”

The study created a mouse model to better understand hair follicle stem cells' role in hair growth and repair.

research Genome-Wide Identification, Characterization, and Expression Analysis of Keratin Genes (KRTs) Family in Yak (Bos Grunniens)

6 citations , January 2022 in “Gene”

Scientists found 53 keratin genes in yaks that are important for hair growth and share similarities with those in other animals.

research Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice

321 citations , March 2015 in “Nature”

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

research Types I and II Keratin Intermediate Filaments

211 citations , April 2018 in “Cold Spring Harbor Perspectives in Biology”

Keratins are crucial for cell structure, growth, and disease risk.

research The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle

87 citations , July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.

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