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GlossaryKeratin 2 (KRT2)

protein providing structural strength to skin, hair, and nails

Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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research Genome-Wide Identification, Characterization, and Expression Analysis of Keratin Genes (KRTs) Family in Yak (Bos Grunniens)

6 citations , January 2022 in “Gene”

Scientists found 53 keratin genes in yaks that are important for hair growth and share similarities with those in other animals.

research Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells

March 2025 in “International Journal of Molecular Sciences”

The study created a mouse model to better understand hair follicle stem cells' role in hair growth and repair.

research A Missense Variant in the Coil1A Domain of the Keratin 25 Gene Is Associated with the Dominant Curly Hair Coat Trait (Crd) in Horses

January 2017

research An Epistatic Effect of KRT25 on SP6 Is Involved in Curly Coat in Horses

13 citations , April 2018 in “Scientific Reports”

The genes KRT25 and SP6 affect curly hair in horses, with KRT25 also causing hair loss. If both genes are mutated, the horse gets curly hair and hair loss. KRT25 can hide the effect of SP6.

Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

3 citations , November 2021 in “Frontiers in Genetics”

Certain genes are linked to the quality of cashmere in goats.

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