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    Glossary Type I Keratin

    Type I keratin is a fibrous protein that is a key structural component of hair, skin, and nails. It is classified as an acidic keratin and is primarily found in the hard tissues of the body, contributing to the strength and resilience of hair strands. In the context of hair loss, understanding type I keratin is relevant as it plays a crucial role in hair follicle health and integrity; any disruption in its production or structure can lead to weakened hair and increased susceptibility to hair loss. Distinguishing characteristics of type I keratin include its high tensile strength and its ability to form complex structures with other keratins, particularly type II keratins, to create the overall architecture of hair.

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    1. Type II Keratins Are Phosphorylated on a Unique Motif during Stress and Mitosis in Tissues and Cultured Cells Molecular Biology of the Cell · 2002 · 80 citations
    2. <i>In vitro</i> Assembly Properties of Human Type I and II Hair Keratins Cell structure and function · 2014 · 12 citations
    3. Seasonal Variability in Transcript Expression of Type I and Type II Keratins in Wool Follicles of Lustrous Fleece-Producing Magra Sheep Journal of Natural Fibers · 2023 · 1 citations
    4. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix Human Genetics · 1997 · 100 citations
    5. Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes Experimental Cell Research · 1995 · 52 citations
    6. A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13 Human Molecular Genetics · 1995 · 54 citations
    7. Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity British Journal of Dermatology · 1997 · 21 citations
    8. The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets? 2005 · 9 citations
    9. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    10. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
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