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GlossaryCOL1A2

gene encoding part of type I collagen, crucial for connective tissues

COL1A2 is a gene that encodes for the alpha-2 chain of type I collagen, which is a crucial protein in the human body. Type I collagen is the most abundant collagen and is essential for the strength and structure of connective tissues, including skin, bones, and tendons. Mutations in the COL1A2 gene can lead to various connective tissue disorders, such as osteogenesis imperfecta, which is characterized by brittle bones.

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research An EGFP-Col4a2 Mouse Model Reveals Basement Membrane Dynamics Underlying Hair Follicle Morphogenesis

December 2024 in “The Journal of Cell Biology”

Basement membrane changes are crucial for hair follicle development.

research Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

59 citations , January 2021 in “Genes”

Twelve key genes may improve cashmere production by influencing hair follicle cycles.

research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase I Study

6 citations , September 2019 in “Skin pharmacology and physiology”

RCS-01 therapy is safe and may improve skin structure by affecting gene expression.

Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray

research Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray

4 citations , October 2014 in “Journal of Integrative Agriculture”

Researchers found 24 genes that change significantly and affect cashmere growth in goats; this could help increase cashmere production.

Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

3 citations , November 2021 in “Frontiers in Genetics”

Certain genes are linked to the quality of cashmere in goats.

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community DUPA, Non Responders and Connective Tissue Disorders

in Research/Science 9 upvotes 9 months ago

A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 4 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.