Implanted Hair-Follicle-Associated Pluripotent Stem Cells Aid Wound Healing and Reduce Scarring in Mice

    August 2022 in “ Research Square (Research Square) ”
    Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ayami Hasegawa, Nanao Takaoka, Ryoichi Aki, Robert M. Hoffman, Yasuyuki Amoh
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    TLDR Implanted special stem cells from hair follicles helped heal wounds faster and with less scarring in mice.
    In a study aimed at improving cutaneous wound healing and reducing scar formation, Hair-follicle-associated pluripotent (HAP) stem cells were cultured into sheets and implanted into dorsal wounds of a mouse model. These HAP stem cells differentiated into keratinocytes, macrophages, and endothelial cells. The results showed that the implanted HAP stem cells not only accelerated wound closure but also increased capillary vessel formation while suppressing macrophage and fibrocyte infiltration and collagen deposition in the dermis. Additionally, the levels of mRNA for TGF-β1, COL1A2, and COL3A1, which are associated with dermal inflammation and fibrosis, were decreased in the HAP-stem-cell-implanted mice compared to the control group. These findings suggest that HAP stem cell implantation has the potential for clinical application in achieving scar-free wound healing.
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