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GlossaryKeratin 5 (KRT5)

protein providing structural support in skin and hair follicles

Keratin 5 (KRT5) is a type of protein found in the skin and hair follicles that helps provide structural support and strength. It is particularly important in the formation of the intermediate filaments in epithelial cells, which are cells that line the surfaces and cavities of the body. Mutations in the KRT5 gene can lead to skin disorders such as epidermolysis bullosa simplex, where the skin becomes fragile and blisters easily.

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Natural Course of Epidermolysis Bullosa Simplex with Mottled Pigmentation in a Japanese Family with the p.P25L Mutation in KRT5

research Natural Course of Epidermolysis Bullosa Simplex with Mottled Pigmentation in a Japanese Family with the p.P25L Mutation in KRT5

3 citations, January 2019 in “Journal of Dermatology”

The p.P25L mutation in the KRT5 gene causes a rare skin condition that worsens over time and may lead to hair loss starting in young adulthood.

Dermatopathology and Molecular Genetics

research Dermatopathology and Molecular Genetics

12 citations, February 2008 in “Journal of The American Academy of Dermatology”

Combining skin tissue pathology with genetics has greatly improved the diagnosis and understanding of certain skin diseases.

Proteomics as a Tool to Improve Novel Insights into Skin Diseases: What We Know and Where We Should Be Going

research Proteomics as a Tool to Improve Novel Insights into Skin Diseases: What We Know and Where We Should Be Going

3 citations, October 2022 in “Frontiers in Surgery”

Proteomics combined with other technologies can lead to a better understanding of skin diseases.

Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

3 citations, November 2021 in “Frontiers in Genetics”

Certain genes are linked to the quality of cashmere in goats.

Distinct Mechanisms for Sebaceous Gland Self-Renewal and Regeneration Provide Durability in Response to Injury

research Distinct Mechanisms for Sebaceous Gland Self-Renewal and Regeneration Provide Durability in Response to Injury

2 citations, May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Sebaceous glands can heal and regenerate after injury using their own stem cells and help from hair follicle cells.

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