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GlossaryKeratin 5 (KRT5)

protein providing structural support in skin and hair follicles

Keratin 5 (KRT5) is a type of protein found in the skin and hair follicles that helps provide structural support and strength. It is particularly important in the formation of the intermediate filaments in epithelial cells, which are cells that line the surfaces and cavities of the body. Mutations in the KRT5 gene can lead to skin disorders such as epidermolysis bullosa simplex, where the skin becomes fragile and blisters easily.

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Natural Course of Epidermolysis Bullosa Simplex with Mottled Pigmentation in a Japanese Family with the p.P25L Mutation in KRT5

research Natural Course of Epidermolysis Bullosa Simplex with Mottled Pigmentation in a Japanese Family with the p.P25L Mutation in KRT5

3 citations , January 2019 in “Journal of Dermatology”

The p.P25L mutation in the KRT5 gene causes a rare skin condition that worsens over time and may lead to hair loss starting in young adulthood.

research Damage of Hair Follicle Stem Cells and Alteration of Keratin Expression in External Radiation-Induced Acute Alopecia

28 citations , June 2012 in “International Journal of Molecular Medicine”

Radiation damages hair stem cells and changes keratin expression, with Krt5 as a potential marker for radiation effects.

research Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate

193 citations , May 2008 in “Development”

Activating β-catenin can turn skin cells into hair follicles.

research Keratins And Disease At A Glance

87 citations , September 2012 in “Journal of Cell Science”

Keratins are crucial for tissue strength, and mutations in keratin genes can lead to various diseases, highlighting the need for targeted therapies.

research Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice

15 citations , May 2014 in “Journal of Biological Chemistry”

A chimeric keratin partially improved skin structure in mice lacking keratin 5, but didn't fully restore normal skin.

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