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GlossaryKeratin 5 (KRT5)

protein providing structural support in skin and hair follicles

Keratin 5 (KRT5) is a type of protein found in the skin and hair follicles that helps provide structural support and strength. It is particularly important in the formation of the intermediate filaments in epithelial cells, which are cells that line the surfaces and cavities of the body. Mutations in the KRT5 gene can lead to skin disorders such as epidermolysis bullosa simplex, where the skin becomes fragile and blisters easily.

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Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

3 citations , November 2021 in “Frontiers in Genetics”

Certain genes are linked to the quality of cashmere in goats.

research Genome-Wide Identification, Characterization, and Expression Analysis of Keratin Genes (KRTs) Family in Yak (Bos Grunniens)

6 citations , January 2022 in “Gene”

Scientists found 53 keratin genes in yaks that are important for hair growth and share similarities with those in other animals.

research Pathological Modeling of Epidermolysis Bullosa Simplex Using Induced Pluripotent Stem Cells

September 2019 in “Journal of Investigative Dermatology”

Scientists used stem cells to create a model of the skin disease Epidermolysis Bullosa simplex, which helped them understand its molecular mechanisms and could aid in finding treatments.

research Natural Course of Epidermolysis Bullosa Simplex with Mottled Pigmentation in a Japanese Family with the p.P25L Mutation in KRT5

3 citations , January 2019 in “Journal of Dermatology”

The p.P25L mutation in the KRT5 gene causes a rare skin condition that worsens over time and may lead to hair loss starting in young adulthood.

research Proteomics as a Tool to Improve Novel Insights into Skin Diseases: What We Know and Where We Should Be Going

3 citations , October 2022 in “Frontiers in Surgery”

Proteomics combined with other technologies can lead to a better understanding of skin diseases.

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