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GlossaryKeratin 1 (KRT1)

protein providing structural support in skin cells

Keratin 1 (KRT1) is a type of protein found in the outer layer of the skin, playing a crucial role in providing structural integrity and resilience. It partners with Keratin 10 to form intermediate filaments, which help skin cells withstand mechanical stress and prevent damage. Mutations in the KRT1 gene can lead to skin disorders such as epidermolytic hyperkeratosis, characterized by blistering and thickened skin.

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Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

research Novel Mutations of the ABCA12, KRT1 and ST14 Genes in Three Unrelated Newborns Showing Congenital Ichthyosis

6 citations, August 2022 in “The Italian Journal of Pediatrics/Italian journal of pediatrics”

New genetic mutations linked to rare skin disorders were found in three newborns.

research Genome-Wide Identification, Characterization, and Expression Analysis of Keratin Genes (KRTs) Family in Yak (Bos Grunniens)

6 citations, January 2022 in “Gene”

Scientists found 53 keratin genes in yaks that are important for hair growth and share similarities with those in other animals.

research Proteomics Analysis of the Secondary Hair Follicle Cycle in Liaoning Cashmere Goat

5 citations, May 2021 in “Small ruminant research”

The study found specific proteins that could mark different growth stages of cashmere goat hair and may help improve cashmere production.

research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

2 citations, August 2020 in “Scientific reports”

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

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