Generation of VEGF Knock-In Cashmere Goat via the CRISPR/Cas9 System

    January 2021 in “ International Journal of Biological Sciences ”
    Xiao Hu, Hao Fei, Xiaocong Li … Dongjun Liu
    Studysummary This study generated a gene-edited cashmere goat with improved cashmere yield and fiber length by integrating VEGF at the FGF5 site, offering insights into hair growth mechanisms.
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    Research cited in this study 7

    1. VEGF165 Induces Differentiation of Hair Follicle Stem Cells Into Endothelial Cells and Plays a Role in In Vivo Angiogenesis Journal of Cellular and Molecular Medicine · 2017
    2. Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers PLoS ONE · 2016
    3. Transcriptional Regulation Analysis and the Potential Transcription Regulator Site in the Extended KAP6.1 Promoter in Sheep Molecular Biology Reports · 2014
    4. Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into the Molecular Basis of Hair Loss in Cetaceans BMC evolutionary biology · 2013
    5. VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway Molecular Biology Reports · 2012
    6. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    7. Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats Journal of Heredity · 2007