TLDR Ultrasound can help deliver genes to cells to stimulate tissue regeneration and enhance hair growth, but more research is needed to perfect the method.
The document "Applications of Ultrasound-Mediated Gene Delivery in Regenerative Medicine" discusses the potential of sonoporation, a non-viral gene delivery method that uses ultrasound to increase the uptake and expression of DNA in cells. This method has been shown to stimulate tissue regeneration in various organ systems, including bone, vascular tissue, cardiac tissue, and pancreatic islets. It has also been used to enhance hair growth and treat androgenic alopecia. Despite promising results, no clinical trials have been conducted yet, and further research is needed to optimize factors such as the type of microbubbles used, the timeline for gene delivery, and the site of injection. The authors are co-founders and shareholders of SonoStem Technologies Inc., a company aiming to commercialize sonoporation-based technologies for tissue regeneration.
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April 2021 in “Frontiers in Pharmacology” Using minoxidil-coated microbubbles with ultrasound significantly boosts hair growth.
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December 2019 in “Biomaterials” Scientists have created a new hair loss treatment using ultrasound to deliver gene-editing particles, which resulted in up to 90% hair regrowth in mice.
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December 2019 in “Biomaterials” Scientists have created a new hair loss treatment using ultrasound to deliver gene-editing particles, which resulted in up to 90% hair regrowth in mice.
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June 2023 in “Journal of Nanobiotechnology” Engineered extracellular vesicles could improve CRISPR/Cas delivery, making gene editing safer and more effective.
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February 2022 in “Acta Biomaterialia” Nanomaterials can improve hair care products and treatments, including hair loss and alopecia, by enhancing stability and safety, and allowing controlled release of compounds, but their safety in cosmetics needs more understanding.
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July 2020 in “ACS Nano” Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.
