Applications of Ultrasound-Mediated Gene Delivery in Regenerative Medicine

The document "Applications of Ultrasound-Mediated Gene Delivery in Regenerative Medicine" discusses the potential of sonoporation, a non-viral gene delivery method that uses ultrasound to increase the uptake and expression of DNA in cells. This method has been shown to stimulate tissue regeneration in various organ systems, including bone, vascular tissue, cardiac tissue, and pancreatic islets. It has also been used to enhance hair growth and treat androgenic alopecia. Despite promising results, no clinical trials have been conducted yet, and further research is needed to optimize factors such as the type of microbubbles used, the timeline for gene delivery, and the site of injection. The authors are co-founders and shareholders of SonoStem Technologies Inc., a company aiming to commercialize sonoporation-based technologies for tissue regeneration.