Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats' Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

    July 2023 in “ Animals ”
    Yuan Gao, Wenjing Song, Hao Fei, Lei Duo, Xiaoshu Zhe, Chunyan Gao, Xudong Guo, Dongjun Liu
    TLDR FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.
    The study used whole-transcriptome sequencing to analyze the role of Fibroblast Growth Factor 10 (FGF10) and a non-coding RNA, miR-184, in the development of secondary hair follicles in cashmere goats. The researchers identified 6468 differentially expressed mRNAs, 394 circRNAs, and 239 miRNAs, which were used to construct a regulatory network for hair follicle development. They found that miR-184 promotes cell proliferation, inhibits apoptosis, and alters the cell cycle by competitively releasing FGF10. The study also revealed that overexpression of miR-184 reduced FGF10 expression, leading to inhibited cell proliferation and increased apoptosis. These findings provide a reference for future studies on hair follicle biology in cashmere goats and other mammals.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 22 results

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 6 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community Comprehensive Microneedling Guide

      in Microneedling  295 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Related Research

    5 / 5 results