Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats' Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

The study used whole-transcriptome sequencing to analyze the role of Fibroblast Growth Factor 10 (FGF10) and a non-coding RNA, miR-184, in the development of secondary hair follicles in cashmere goats. The researchers identified 6468 differentially expressed mRNAs, 394 circRNAs, and 239 miRNAs, which were used to construct a regulatory network for hair follicle development. They found that miR-184 promotes cell proliferation, inhibits apoptosis, and alters the cell cycle by competitively releasing FGF10. The study also revealed that overexpression of miR-184 reduced FGF10 expression, leading to inhibited cell proliferation and increased apoptosis. These findings provide a reference for future studies on hair follicle biology in cashmere goats and other mammals.