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Glossary Regulatory Network

interactions controlling gene expression within a cell

A Regulatory Network, often referred to as a Gene Regulatory Network (GRN), is a complex system of interactions between genes, proteins, and other molecules that control the expression levels of genes within a cell. These networks are crucial for determining how cells respond to various signals and environmental conditions, ultimately influencing processes like development, differentiation, and disease.

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Research

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LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

research LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

25 citations , August 2017 in “Animal Biotechnology”

This study identified and characterized several long noncoding RNAs in Cashmere goats, revealing complex regulatory roles in hair follicle development and growth, particularly within the Wnt signaling pathway.

research Regulatory network of ginsenoside biosynthesis under Ro stress in the hairy roots of Panax ginseng revealed by RNA sequencing

5 citations , October 2022 in “Frontiers in bioengineering and biotechnology”

Ro stress hindered ginseng root growth and ginsenoside production, but increased certain hormones and affected gene regulation related to plant growth and stress responses.

Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms

3 citations , May 2023 in “Precision clinical medicine”

This study analyzed gene expression data to identify key genes involved in severe forms of alopecia areata, discovering four immune monitoring genes (LGR5, SHISA2, HOXC13, S100A3) with potential for early diagnosis and better understanding of the disease's biological mechanisms.

Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats

research Construction and functional analysis of ceRNA regulatory network related to the development of secondary hair follicles in Inner Mongolia cashmere goats

2 citations , August 2022 in “Frontiers in Veterinary Science”

This study constructed a ceRNA regulatory network related to cashmere goat secondary hair follicle development, highlighting the role of circRNA in their morphogenesis through the ceRNA mechanism.

research RSL4 regulatory network acts as an early driver of root hair growth at low temperature in Arabidopsis thaliana

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, researchers identified a gene regulatory network in Arabidopsis that controls root hair growth under low-temperature conditions, revealing specific transcription factors and downstream targets that contribute to this growth response despite overall plant development being halted.

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community The ANSM is trying to ban Finasteride

in Research/Science 110 upvotes 1 year ago

France is considering reviewing finasteride and dutasteride due to concerns about their safety, but a ban in the EU is unlikely due to regulatory hurdles. Many users express frustration over the potential ban, emphasizing the effectiveness of finasteride for hair loss and criticizing the influence of anecdotal evidence on public health policy.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Finasteride is save in the eu (they concluded the investigation)

in Finasteride/Dutasteride 335 upvotes 1 year ago

Finasteride and dutasteride are still available in the EU, with a warning about potential suicidal thoughts. The benefits of these treatments are deemed greater than the risks.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community People's ignorance on MPB is both frustrating and harmful to balding men and it's important to educate other balding men on Fin/Min/Dut (Discussion)

156 upvotes 1 year ago

Many are unaware of effective male pattern baldness treatments like finasteride and minoxidil, often opting for ineffective remedies. Educating others on proven treatments and potential side effects is crucial.

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learn Beta Polypeptide

learn Thymosin Beta 4

learn Stem Cell Factor

learn Vascular Endothelial Growth Factor

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