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    Glossary Regulatory Network

    interactions controlling gene expression within a cell

    A Regulatory Network, often referred to as a Gene Regulatory Network (GRN), is a complex system of interactions between genes, proteins, and other molecules that control the expression levels of genes within a cell. These networks are crucial for determining how cells respond to various signals and environmental conditions, ultimately influencing processes like development, differentiation, and disease.

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    1. LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway Animal Biotechnology · 2017 · 25 citations
    2. Regulatory network of ginsenoside biosynthesis under Ro stress in the hairy roots of Panax ginseng revealed by RNA sequencing Frontiers in bioengineering and biotechnology · 2022 · 5 citations
    3. Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms Precision clinical medicine · 2023 · 3 citations
    4. Construction and functional analysis of ceRNA regulatory network related to the development of secondary hair follicles in Inner Mongolia cashmere goats Frontiers in Veterinary Science · 2022 · 2 citations
    5. RSL4 regulatory network acts as an early driver of root hair growth at low temperature in Arabidopsis thaliana bioRxiv (Cold Spring Harbor Laboratory) · 2024
    6. A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions Nature Communications · 2025 · 13 citations
    7. MicroRNA/mRNA regulatory networks in the control of skin development and regeneration Cell Cycle · 2012 · 56 citations
    8. The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat Scientific Reports · 2018 · 13 citations
    9. LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials Frontiers in physiology · 2023 · 3 citations
    10. 183 PD-1 regulatory network is upregulated in contact immunotherapy during alopecia areata treatment Journal of Investigative Dermatology · 2023
    11. Whole-transcriptome RNA sequencing reveals global expression dynamics and ceRNA regulatory networks related to hair follicle development and melanogenesis in goats Animal Bioscience · 2025
    12. Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats BMC Genomics · 2018 · 50 citations
    13. Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer Animals · 2023
    14. 1392 Activation of Id2 gene regulatory network ruling quiescence of hair follicle stem cells Journal of Investigative Dermatology · 2018
    15. LncRNA-000133 from secondary hair follicle of Cashmere goat: identification, regulatory network and its effects on inductive property of dermal papilla cells Animal Biotechnology · 2019 · 18 citations
    16. Study on the regulatory effect of Ligusticum chuanxiong on inflammation of human dermal papilla cells in alopecia areata based on network pharmacology and in vitro experiment Research Square · 2024
    17. Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles Czech Journal of Animal Science · 2022 · 7 citations
    18. miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network Frontiers in Cell and Developmental Biology · 2022
    19. N6-methyladenosine (m6A)-circHECA from secondary hair follicle of cashmere goats: identification, regulatory network and expression regulated potentially by methylation of its host gene promoter Animal Bioscience · 2024 · 2 citations
    20. Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets Health Science Reports · 2026
    21. Network-Based Drug Repositioning: Approaches, Resources, and Research Directions Methods in molecular biology · 2018 · 39 citations
    22. Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging Scientific Reports · 2021 · 12 citations
    23. Regulatory Mechanisms of Natural Active Ingredients and Compounds on Keratinocytes and Fibroblasts in Mitigating Skin Photoaging Clinical Cosmetic and Investigational Dermatology · 2024 · 10 citations
    24. Pathway enrichment and network analysis of differentially expressed genes in pashmina goat Gene reports · 2022 · 1 citations
    25. Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach Journal of Investigative Dermatology · 2013 · 28 citations
    26. Repigmentation Competence in Vitiligo: Integrating Immune, Regulatory, Regenerative, and Microenvironmental Axes Journal of Personalized Medicine · 2026
    27. Hair biology: an update International Journal of Cosmetic Science · 2002 · 11 citations
    28. Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology Animals · 2023 · 2 citations
    29. Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats Frontiers in Veterinary Science · 2025 · 2 citations
    30. Phenotypic heterogeneity in human genetic diseases: ultrasensitivity-mediated threshold effects as a unifying molecular mechanism Journal of Biomedical Science · 2023