Hair Biology: An Update

February 2002 in “ International Journal of Cosmetic Science ”

Bruno Bernard

hair follicle growth cycle regeneration cycle tissue organization regulatory network hair growth pigmentation tissue homeostasis dermal-epithelial crosstalk molecular signals

Studysummary This review describes recent findings in hair biology, highlighting the diverse molecular signals that regulate hair growth and pigmentation, but presents no new experimental results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis

303 citations , October 2000 in “Nature”

This study found that RXRα plays a critical role in hair cycling and keratinocyte functions in mice, likely through its interaction with VDR in epidermal cells.

research Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

51 citations , September 2000 in “Acta dermato-venereologica”

This study found that PPAR alpha, -delta, and -gamma are expressed in human hair follicle cells, and clofibrate exhibited a beneficial effect on hair follicle survival in culture within a specific concentration range.

research Melanocyte Subpopulation Turnover During the Human Hair Cycle: An Immunohistochemical Study

86 citations , August 2000 in “Pigment cell research”

This study observed that melanogenesis in human hair follicles is linked to anagen phases, with melanocyte activity and enzyme expression being region-specific to the nascent bulb.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.

research Androgenetic Alopecia and Microinflammation

131 citations , August 2000 in “International Journal of Dermatology”

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

research Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle

111 citations , April 2000 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, physiological levels of free T3 significantly enhanced the survival of human hair follicles in vitro.

research Expression of Retinoid Nuclear Receptor Superfamily Members in Human Hair Follicles and Its Implication in Hair Growth

34 citations , September 1997 in “Acta Dermato Venereologica”

This study found that RXR agonists stimulated human hair follicle growth and survival in vitro, suggesting potential for promoting hair growth in humans.

research Immunohistochemical Analysis of Tissue Remodeling During the Anagen-Catagen Transition of the Human Hair Follicle

47 citations , July 1997 in “British Journal of Dermatology”

This research observed that during the catagen phase, the inner root sheath of hair follicles becomes an early target, highlighting its potential role in maintaining hair follicle homeostasis.

research Androgens and Human Hair Growth

157 citations , April 1994 in “Clinical endocrinology”

Androgens can cause hair growth in some areas and hair loss on the scalp.

research Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells

62 citations , June 1993 in “Archives of Dermatological Research”

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.

research Growth Factors Specifically Alter Hair Follicle Cell Proliferation and Collagenolytic Activity Alone or in Combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.