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Glossary Hair Growth Cycle

process where hair follicles undergo growth, transition, and rest phases

The Hair Growth Cycle, also known as Hair Follicle Cycling, consists of three main phases: anagen (growth phase), catagen (transitional phase), and telogen (resting phase). During the anagen phase, hair actively grows from the follicle, which can last several years. The catagen phase is a short period where growth stops, and the hair follicle shrinks. Finally, in the telogen phase, the hair rests before eventually falling out, making way for new hair to begin the cycle again. Understanding these phases is crucial for diagnosing and treating hair loss conditions like alopecia.

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Research

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research Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth

3 citations , August 2020 in “International Journal of Molecular Sciences”

This study found that Rab27a and Rab27b play opposite roles in hair growth, with Rab27a knockdown suppressing and Rab27b knockdown promoting hair growth in models.

research Growth of the Mouse Coat VII. Hair Cycles and Sebaceous Glands in Homozygous and Heterozygous Naked Mice

2 citations , January 1960 in “Australian Journal of Biological Sciences”

The Naked gene in mice causes abnormal sebaceous glands and disrupts hair follicle organization.

research Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

104 citations , January 2023 in “Journal of Clinical Medicine”

This review evaluates the hair cycle's phases and the factors influencing the transition between anagen and telogen, advocating for a holistic approach to addressing hair loss, though no specific results are reported.

research Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

100 citations , November 1996 in “Molecular Medicine Today”

This review discusses the role of growth factors and cytokines in hair follicle development and cycling, but reports no new clinical findings on treatments for hair growth disorders.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

90 citations , October 1996 in “Dermatologic Clinics”

This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.

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Community Join

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community Circadian rhythm disruption and its potential impact on hair growth cycles

in Technology 7 upvotes 4 months ago

Poor sleep quality may affect hair growth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hair growth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.

community Scalp hydration's surprising link to hair growth cycle regulation

in Technology 23 upvotes 4 months ago

Scalp hydration may influence hair growth by affecting the signaling pathways that control the hair growth cycle. Users suggest using facial moisturizer, aloe vera, and oils for scalp hydration.

community OND-1 "Cyclosporine A” New hair loss treatment

in Research/Science 28 upvotes 5 months ago

Orient Bio is developing a PLGA formulated version of Cyclosporine A to stimulate hair growth without its immunosuppressant effects. Users discuss various treatments like Clascoterone, PP405, minoxidil, and tacrolimus, expressing hope for new developments and sharing personal experiences with these treatments.

community Growth? (Only dut for 3 months)

in Is this regrowth? 19 upvotes 2 years ago

A user used dutasteride 0.5mg for 3 months and is unsure about hair regrowth, noting some greying. Responses suggest improvement and that full regrowth may take time with shedding cycles.

community Scalp Skin Barrier Health and Hair Follicle Cycling: A Potential Overlooked Connection

in Technology 4 months ago

The conversation discusses the importance of scalp skin barrier health in hair follicle cycling, suggesting treatments like ceramides or niacinamide to support hair growth. It also mentions the use of finasteride for hair loss.

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Learn

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learn Hair Transplant

When will I see new hair growth after a hair transplant? New hair growth usually starts 2-4 months after a hair transplant.
What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.

learn Follistatin

Protein that blocks activin, a growth-regulating signal

What is follistatin, and how does it influence hair follicle growth and regeneration? Follistatin blocks activin and related growth-inhibiting proteins, which mouse studies link to hair follicle development and cycling; the only verifiable human evidence is a single small 2011 phase 1 injection trial, so follistatin remains experimental and is not an approved hair-loss treatment.

learn Stem Cell Factor

learn KY19382

Experimental compound that activates hair-growth signals, tested only in animals

learn Bimatoprost

Prostaglandin eye drop used for glaucoma and eyelash growth

learn Vitis vinifera

What is Vitis vinifera, and does it benefit hair health? Grape (Vitis vinifera) extracts show antioxidant activity in lab studies and affected the hair cycle in mice, but no human trial shows they help hair growth.

learn Procyanidin

Plant polyphenol found in apples and grape seeds

learn Caffeine

Does caffeine stimulate hair growth or only slow hair loss? Caffeine stimulates hair follicles in laboratory cultures, and one open-label, manufacturer-funded trial in 210 men found a 0.2% caffeine topical non-inferior to minoxidil 5% on an anagen-ratio endpoint. A 2025 systematic review found only a few small controlled trials, mostly rated low or very low quality, and none in alopecia areata.

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