Growth of the Mouse Coat VII: Hair Cycles and Sebaceous Glands in Homozygous and Heterozygous Naked Mice

    January 1960 in “ Australian Journal of Biological Sciences ”
    T Nay
    Image of study
    TLDR The Naked gene in mice causes abnormal sebaceous glands and disrupts hair follicle organization.
    The study on the Naked gene (N) in mice found that while it does not affect the timing of hair cycles, it has additive effects on keratinization and sebaceous glands. Involving 30 mice, the research showed no significant difference in hair cycle timing between homozygous (NN) and heterozygous (N+) mice. However, homozygous mice displayed more pronounced abnormalities in sebaceous glands, with separated ducts opening independently on the skin surface, unlike the ampulla formation in heterozygous mice. The Naked gene disrupts hair follicle organization, leading to impaired keratinization and abnormal sebaceous gland development.
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