LncRNAs Regulate the Cyclic Growth and Development of Hair Follicles in Dorper Sheep

    Hui Sun, Ke Meng, Yifan Wang … Xinhai Li
    Studysummary In this study, researchers analyzed skin samples from Dorper sheep to identify 395 differentially expressed long non-coding RNAs (lncRNAs) linked to hair follicle growth phases, suggesting these lncRNAs may play a role in the regulation of hair shedding through pathways like estrogen and PI3K-Akt signaling.
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    Research cited in this study 25

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Integrated Analysis of lncRNAs and mRNAs by RNA-Seq in Secondary Hair Follicle Development and Cycling (Anagen, Catagen, and Telogen) of Jiangnan Cashmere Goat (Capra hircus) BMC Veterinary Research · 2022
    3. Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads Journal of Bioscience and Bioengineering · 2022
    4. Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway International journal of biological macromolecules · 2022
    5. Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus BMC Genomics · 2022
    6. Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in In Vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures Frontiers in cell and developmental biology · 2021
    7. Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice Frontiers in Pharmacology · 2021
    8. Proteomics Analysis of the Secondary Hair Follicle Cycle in Liaoning Cashmere Goat Small ruminant research · 2021
    9. Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats Genes · 2021
    10. Platelet Factor 4 Inhibits Human Hair Follicle Growth and Promotes Androgen Receptor Expression in Human Dermal Papilla Cells PeerJ · 2020
    11. Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling Stem Cells · 2019
    12. Hair Follicle Differentiation-Specific Keratin Expression in Human Basal Cell Carcinoma Clinical and Experimental Dermatology · 2019
    13. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle Journal of Molecular Cell Biology · 2018
    14. Integrative Analysis Reveals ncRNA-Mediated Molecular Regulatory Network Driving Secondary Hair Follicle Regression in Cashmere Goats BMC Genomics · 2018
    15. LncRNA PlncRNA-1 Regulates Proliferation and Differentiation of Hair Follicle Stem Cells Through TGF-β1-Mediated Wnt/β-Catenin Signal Pathway Molecular Medicine Reports · 2017
    16. Integrated Analysis of Coding Genes and Non-Coding RNAs During Hair Follicle Cycle of Cashmere Goat (Capra Hircus) BMC Genomics · 2017
    17. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    18. LHX2 Is a Direct NF-κB Target Gene That Promotes Primary Hair Follicle Placode Down-Growth Development · 2016
    19. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    20. Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep International Journal of Molecular Sciences · 2015
    21. Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration Experimental Dermatology · 2014
    22. Hair Curvature: A Natural Dialectic and Review Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2014
    23. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    24. Annotation of Sheep Keratin Intermediate Filament Genes and Their Patterns of Expression Experimental Dermatology · 2011
    25. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001