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    GlossaryRegulatory Network

    interactions controlling gene expression within a cell

    A Regulatory Network, often referred to as a Gene Regulatory Network (GRN), is a complex system of interactions between genes, proteins, and other molecules that control the expression levels of genes within a cell. These networks are crucial for determining how cells respond to various signals and environmental conditions, ultimately influencing processes like development, differentiation, and disease.

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      learn Tretinoin

      the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

      learn Valproic acid

      an anticonvulsant repurposed for hair loss via histone inhibition

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      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community why hair restoration has not been progressed for last 20 years?

      in Chat  34 upvotes 1 year ago
      The conversation discusses the lack of significant advancements in hair loss treatments beyond finasteride and minoxidil, questioning if hair restoration technology has reached a dead end. Hair transplant technology has improved, but new medications face challenges with market entry, cost, accessibility, and long-term effectiveness.

      community FINASTRIDE and switch to DUTASTRIDE, my experience

      in Progress Pictures  138 upvotes 3 months ago
      The user shared their experience with Finasteride and Dutasteride for hair loss. They initially had success with Finasteride but switched to Dutasteride after experiencing shedding, which continued, and are now considering a hair transplant.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 5 months ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.