MicroRNA/mRNA Regulatory Networks in the Control of Skin Development and Regeneration

February 2012 in “ Cell Cycle ”

Natalia V. Botchkareva

microRNAs miRNAs gene regulation skin homeostasis epidermal differentiation hair cycle pigmentation miR-203 DeltaNp63 keratinocyte survival keratinocyte migration hair follicle regeneration melanocyte development p63 MITF miRNA-based therapeutic approaches

TLDR MicroRNAs are crucial for controlling skin development and healing by regulating genes.

The 2012 document reviews the role of microRNAs (miRNAs) in skin development, regeneration, and pigmentation, emphasizing their importance in gene regulation for maintaining skin homeostasis. It explains how miRNAs control gene expression related to cell type-specific transcription, epidermal differentiation, hair cycle, and pigmentation, with specific examples such as miR-203's impact on epidermal differentiation by targeting DeltaNp63. The review also discusses the involvement of miRNAs in the regulation of keratinocyte survival and migration, hair follicle regeneration, and melanocyte development, highlighting the feedback loops with master regulators like p63 and MITF. It suggests that further research into miRNA/mRNA networks could lead to miRNA-based therapeutic approaches for skin conditions. The research was supported by a Royal Society Research Grant and Centre for Skin Sciences funds at the University of Bradford.

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