Activation of Id2 Gene Regulatory Network Ruling Quiescence of Hair Follicle Stem Cells

    May 2018 in “ Journal of Investigative Dermatology ”
    Xuchen Wang, Gang Wang, Raúl Ramos, Xiaoyang Wang, Patrycja Daszczuk, Paweł Mazurek, Kyuson Yun, Mark A. Israel, Maksim V. Plikus, Krzysztof Kobielak
    TLDR Id2 gene helps keep hair follicle stem cells inactive.
    The study investigated the role of the Id2 gene in hair follicle stem cells (hfSCs) by using a transgenic mouse model with Id2 overexpression. The results showed that Id2 overexpression led to prolonged telogen and delayed anagen activation, maintaining stem cell quiescence. RNA-seq analysis revealed that approximately 10% of genes were affected by Id2 overexpression, with about half of these genes overlapping with those influenced by the BMP pathway, indicating a synergistic relationship. However, the other half of the genes appeared to function independently of BMP signaling, suggesting a complex gene regulatory network governing hfSC quiescence.
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