Molecular Network of Smads and Id2 Genes in Hair Follicle Stem Cells Regulation

    May 2017 in “ Journal of Investigative Dermatology ”
    Krzysztof Kobielak, X. Wang, G. Wang, Agnieszka Kikulska, Patrycja Daszczuk, Y. Chen, Maksim V. Plikus, Kyuson Yun, Mark A. Israel, Eve Kandyba
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    TLDR The BMP/Smads pathway and Id2 gene control hair follicle stem cells, affecting their rest and growth phases.
    The document detailed a study on the role of Smads and Id2 genes in hair follicle stem cells (hfSCs) regulation. Using an inducible Bmprla transgenic system and ChipSeq analysis, researchers found that 72% of genes affected by BMP ablation in hfSCs were directly regulated by the BMP/Smads pathway. The study confirmed that the Id2 gene is a direct target of BMP signaling and that its overexpression in hfSCs leads to a prolonged resting phase and delayed hair growth phase, keeping stem cells in a dormant state. This research highlighted the importance of the BMP/Smads pathway and the Id2 gene in the maintenance of hfSCs.
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