An Integrative Analysis of the LncRNA-MiRNA-mRNA Competitive Endogenous RNA Network Reveals Potential Mechanisms in the Murine Hair Follicle Cycle

October 2022 in “ Frontiers in Genetics ”

Yuxin Ding, Yuhong Chen, Xiaoshuang Yang, Piaopiao Xu, Jing Jing, Yu-Jie Miao, Meiqi Mao, Jiali Xu, Xianjie Wu, Lu Zhang

lncRNA miRNA mRNA competitive endogenous RNA ceRNA hair follicle cycle anagen phase telogen phase GSPT1 gene androgenetic alopecia alopecia hair growth signaling pathways hair growth hair loss hair cycle growth phase rest phase

TLDR The research found new potential mechanisms in mouse hair growth by studying RNA interactions.

The research paper "An integrative analysis of the lncRNA-miRNA-mRNA competitive endogenous RNA network reveals potential mechanisms in the murine hair follicle cycle" investigates the role of noncoding RNAs and the competitive endogenous RNA (ceRNA) network in the hair follicle cycle of mice. The study found that the expression of 11 miRNAs increased, while the expression of 105 target mRNAs and 16 target lncRNAs decreased from the anagen (growth) to telogen (rest) phase. The researchers constructed ceRNA networks consisting of 123 interactive miRNA-mRNA pairs and 42 miRNA-lncRNA pairs. The functional enrichment analysis revealed the involvement of these networks in hair growth–related signaling pathways. The GSPT1 gene was found to be downregulated in patients with androgenetic alopecia, suggesting a possible association with alopecia progression. The study used scalp samples from 14 patients with androgenetic alopecia and 14 healthy individuals.

View this study on frontiersin.org →

Discuss this study in the Community →

Cited in this study

19 / 19 results

research Diagnosis and Treatment of Nonscarring Hair Loss in Primary Care in 2021

4 citations , March 2021 in “JAMA”

Primary care in 2021 focused on identifying nonscarring hair loss and managing common types based on the pattern of hair loss.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , February 2020 in “American Journal of Clinical Dermatology”

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

research Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options

19 citations , September 2019 in “Expert Opinion on Therapeutic Targets”

New treatments for hair loss may target specific pathways and generate new hair follicles.

research Retracted Article: Up-Regulated lncRNA5322 Elevates MAPK1 to Enhance Proliferation of Hair Follicle Stem Cells as a ceRNA of microRNA-19b-3p

9 citations , June 2019 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations , June 2019 in “Cell reports”

Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

research Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

27 citations , October 2017 in “British Journal of Dermatology”

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

research Genomewide Differential Expression Profiling of Long Non-Coding RNAs in Androgenetic Alopecia in a Chinese Male Population

11 citations , August 2017 in “Journal of The European Academy of Dermatology and Venereology”

Found different long non-coding RNAs in balding Chinese men, which may help create new treatments.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , July 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations , October 2015 in “Cell reports”

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway

103 citations , November 2014 in “Journal of Cell Biology”

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

research Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles

28 citations , December 2012 in “Experimental dermatology”

A protein complex called mTORC1 likely affects when hair growth starts in mice.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research MicroRNA/mRNA Regulatory Networks in the Control of Skin Development and Regeneration

56 citations , February 2012 in “Cell Cycle”

MicroRNAs are crucial for controlling skin development and healing by regulating genes.

research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

149 citations , June 2010 in “The FASEB journal”

miR-31 regulates hair growth by controlling gene expression in hair follicles.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

2 / 2 results

research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

21 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.