An Integrative Analysis of the LncRNA-MiRNA-mRNA Competitive Endogenous RNA Network Reveals Potential Mechanisms in the Murine Hair Follicle Cycle

October 2022 in “ Frontiers in Genetics ”

Yuxin Ding, Yuhong Chen, Xiaoshuang Yang, Piaopiao Xu, Jing Jing, Yu-Jie Miao, Meiqi Mao, Jiali Xu, Xianjie Wu, Lu Zhang

lncRNA miRNA mRNA competitive endogenous RNA ceRNA hair follicle cycle anagen phase telogen phase GSPT1 gene androgenetic alopecia alopecia hair growth signaling pathways hair growth hair loss hair cycle growth phase rest phase

TLDR The research found new potential mechanisms in mouse hair growth by studying RNA interactions.

The research paper "An integrative analysis of the lncRNA-miRNA-mRNA competitive endogenous RNA network reveals potential mechanisms in the murine hair follicle cycle" investigates the role of noncoding RNAs and the competitive endogenous RNA (ceRNA) network in the hair follicle cycle of mice. The study found that the expression of 11 miRNAs increased, while the expression of 105 target mRNAs and 16 target lncRNAs decreased from the anagen (growth) to telogen (rest) phase. The researchers constructed ceRNA networks consisting of 123 interactive miRNA-mRNA pairs and 42 miRNA-lncRNA pairs. The functional enrichment analysis revealed the involvement of these networks in hair growth–related signaling pathways. The GSPT1 gene was found to be downregulated in patients with androgenetic alopecia, suggesting a possible association with alopecia progression. The study used scalp samples from 14 patients with androgenetic alopecia and 14 healthy individuals.

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