Preliminary Study on MicroR-148a and MicroR-10a in Dermal Papilla Cells of Hu Sheep

August 2019 in “ BMC Genetics ”

Xiaoyang Lv, Wen Gao, Chengyan Jin, Lihong Wang, Yue Wang, Weihao Chen, Shuangxia Zou, Sainan Huang, Li Z, Jinyu Wang, Wei Sun

microR-148a microR-10a dermal papilla cells hair follicle growth BMP7 Smad proteins TGF-β microRNA-148a microRNA-10a transforming growth factor beta

Studysummary This study identified a target relationship between miR-148a, miR-10a, and BMP7, suggesting these microRNAs influence dermal papilla cell proliferation and may regulate hair follicle growth. Our plain-language summary of this paper — not a Tressless recommendation.

This preliminary study on Hu sheep dermal papilla cells explored the roles of microRNAs miR-148a and miR-10a in hair follicle growth and development. It identified BMP7 as a target gene for both microRNAs, showing that they inhibited BMP7 expression at mRNA and protein levels. Overexpression of these microRNAs decreased dermal papilla cell proliferation, while inhibition increased it. The study also noted changes in Smad proteins and TGF-β expression, suggesting that miR-148a and miR-10a influenced hair follicle development through BMP7 regulation. These findings laid the groundwork for further research into the molecular mechanisms of hair follicle growth mediated by these microRNAs.

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