MiRNA in Regulation of Skin and Hair Follicle Development

October 2013 in “ Yichuan ”

Ting Cai, Zhihong Liu, Zhixin Wang, Meng Zhao, Hong-Li Ju, Jinquan Li

miRNA microRNA epidermal development hair follicle regeneration hair follicle development pigmentation signal pathways regulatory factors epidermal homeostasis gene regulatory network

TLDR miRNAs are key in skin and hair growth and maintenance.

Recent research demonstrated that miRNAs played crucial roles in the regulation of epidermal development and cyclic hair follicle regeneration by showing tissue-specific and stage-specific expression patterns. A large number of miRNAs were involved in epidermis and hair follicle development, pigmentation, and cyclical hair follicle development. These miRNAs formed a comprehensive, multi-level network system through interactions with signal pathways and regulatory factors. The review summarized progress on miRNAs' roles in controlling epidermal homeostasis and hair follicle development, contributing to gene regulatory network research, disease treatment, and molecular breeding.

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