Expression Characteristics of BMP2, BMPR-IA, and Noggin in Different Stages of Hair Follicle in Yak Skin

    November 2017 in “ General and comparative endocrinology ”
    Lianchun Song, Yan Cui, Sijiu Yu, Jun Li, Xue Yang, Junlin He, Qian Zhang
    Studysummary This study found that BMP2 and BMPR-IA inhibited, while Noggin promoted, hair follicle growth in yaks by affecting skin epithelial cell activity. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the expression profiles of BMP2, BMPR-IA, and Noggin in the hair follicle (HF) cycle of yak skin. BMP2 and BMPR-IA were found to inhibit HF growth, with their highest expression levels during the telogen phase. In contrast, Noggin promoted HF growth, showing significantly higher expression in the proanagen and midanagen phases, with the peak in the proanagen phase. These proteins were expressed in various skin structures, including the epidermis and hair matrix, indicating that they regulate the HF cycle by affecting skin epithelial cell activity. The findings provided insights into the molecular regulation of HF development in yaks.
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