Retracted Article: Up-Regulated lncRNA5322 Elevates MAPK1 to Enhance Proliferation of Hair Follicle Stem Cells as a ceRNA of microRNA-19b-3p

June 2019 in “ Cell cycle/Cell cycle (Georgetown, Tex. Online) ”

Bingjie Cai, Xinxin Wang, Hongtao Liu, Shanshan Ma, Kun Zhang, Yanting Zhang, Qinghua Li, Junmin Wang, Minghao Yao, Fangxia Guan, Guangwen Yin

lncRNA5322 MAPK1 hair follicle stem cells HFSC competing endogenous RNA ceRNA microRNA-19b-3p miR-19b-3p wound contraction epidermal regeneration

TLDR A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

The retracted study investigated the role of lncRNA5322 in hair follicle stem cell (HFSC) proliferation, finding that up-regulation of lncRNA5322 enhanced HFSC proliferation and colony formation by acting as a competing endogenous RNA (ceRNA) for miR-19b-3p, which targets MAPK1. This up-regulation also promoted wound contraction and epidermal regeneration in a mouse model. The findings suggested that the lncRNA5322/miR-19b-3p/MAPK1 pathway could be crucial for HFSC functions and wound healing, although the retraction indicates that these results should be interpreted with caution.

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research LncRNA PlncRNA-1 Regulates Proliferation and Differentiation of Hair Follicle Stem Cells Through TGF-β1-Mediated Wnt/β-Catenin Signal Pathway

25 citations , November 2017 in “Molecular Medicine Reports”

PlncRNA-1 helps hair follicle stem cells grow and develop by controlling a specific cell signaling pathway.

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

37 citations , April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

research Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny

61 citations , December 2016 in “The EMBO Journal”

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

research Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations , October 2015 in “Cell reports”

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

research Gelatin-Chondroitin-6-Sulfate-Hyaluronic Acid Scaffold Seeded with Vascular Endothelial Growth Factor 165 Modified Hair Follicle Stem Cells as a Three-Dimensional Skin Substitute

45 citations , October 2014 in “Stem cell research & therapy”

Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.