Retracted Article: Up-Regulated lncRNA5322 Elevates MAPK1 to Enhance Proliferation of Hair Follicle Stem Cells as a ceRNA of microRNA-19b-3p

June 2019 in “ Cell cycle/Cell cycle (Georgetown, Tex. Online) ”

Bingjie Cai, Xinxin Wang, Hongtao Liu, Shanshan Ma, Kun Zhang, Yanting Zhang, Qinghua Li, Junmin Wang, Minghao Yao, Fangxia Guan, Guangwen Yin

lncRNA5322 MAPK1 hair follicle stem cells HFSC competing endogenous RNA ceRNA microRNA-19b-3p miR-19b-3p wound contraction epidermal regeneration

Studysummary A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

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The retracted study investigated the role of lncRNA5322 in hair follicle stem cell (HFSC) proliferation, finding that up-regulation of lncRNA5322 enhanced HFSC proliferation and colony formation by acting as a competing endogenous RNA (ceRNA) for miR-19b-3p, which targets MAPK1. This up-regulation also promoted wound contraction and epidermal regeneration in a mouse model. The findings suggested that the lncRNA5322/miR-19b-3p/MAPK1 pathway could be crucial for HFSC functions and wound healing, although the retraction indicates that these results should be interpreted with caution.

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