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Glossary competing endogenous RNA

molecules that regulate gene expression by sequestering microRNAs

Competing endogenous RNAs (ceRNAs) are molecules within cells that can regulate gene expression by "competing" for shared microRNAs. Essentially, they act like sponges, binding to microRNAs and preventing these microRNAs from attaching to their usual target messenger RNAs (mRNAs), which would otherwise inhibit the production of certain proteins. This mechanism plays a crucial role in various biological processes and diseases, including cancer and hair loss conditions like alopecia.

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research Differential expression patterns of specific long noncoding RNAs and competing endogenous RNA network in alopecia areata

10 citations , February 2019 in “Journal of Cellular Biochemistry”

This study reports a complex network of blood lncRNA and associated pathways in alopecia areata but suggests further research is needed for verification and understanding of these findings.

research Biological Function of Long Non-coding RNA (LncRNA) Xist

247 citations , June 2021 in “Frontiers in Cell and Developmental Biology”

This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.

research lncRNA H19 acts as a ceRNA to regulate the expression of CTGF by targeting miR-19b in polycystic ovary syndrome

21 citations , January 2020 in “Brazilian Journal of Medical and Biological Research”

This study found that lncRNA H19 may regulate CTGF expression in KGN cells by acting as a "sponge" for miR-19b, potentially influencing polycystic ovary syndrome development.

research Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats

17 citations , June 2019 in “BMC genomics”

This study cataloged several long non-coding RNAs and microRNAs in cashmere goat dermal papilla cells, suggesting these non-coding RNAs may play a role in hair follicle stem cell activation and hair growth.

research RETRACTED ARTICLE: Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p

9 citations , June 2019 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Where do you guys get Topilutamide from? (if you even do)

in Chat 5 upvotes 4 months ago

The conversation discusses sourcing Topilutamide (fluridil) as a treatment for hair loss, with users comparing it to RU58841 and finasteride. Users share their experiences with various treatments, including testosterone, DHT gel, and Proviron, while expressing difficulty in finding Topilutamide.

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