Differential Expression Patterns of Specific Long Noncoding RNAs and Competing Endogenous RNA Network in Alopecia Areata

    February 2019 in “ Journal of Cellular Biochemistry ”
    Yuan Sheng, Jingwen Ma, Jun Zhao, Shaohua Qi, Ruiming Hu, Qinping Yang
    TLDR Specific RNA patterns are linked to alopecia areata.
    The study investigated the role of long noncoding RNAs (lncRNAs) and their related competing endogenous RNA (ceRNA) network in alopecia areata (AA) by analyzing blood samples from 5 individuals with AA and 5 normal controls. Researchers identified 154 differentially expressed lncRNAs and 46 differentially expressed genes (DEGs), with functional enrichment analysis indicating involvement in pathways such as focal adhesion and Mucin type O-glycan biosynthesis. A ceRNA network was constructed, revealing six subnetworks, with subnetwork 1 significantly associated with AA. The study concluded that there were distinct blood lncRNA expression patterns and a complex ceRNA network in AA, but further research was needed to verify these findings in blood and tissue samples.
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