Hair Follicle Specific ACVR1/ALK2 Critically Affects Skin Morphogenesis and Attenuates Wound Healing
May 2017
in “
Wound Repair and Regeneration
”
Studysummary In this study, targeted overexpression of the BMP receptor ALK2 in mouse hair follicle stem cells altered follicle structure and impaired cutaneous wound healing.
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The study investigated the role of the BMP receptor ALK2/ACVR1 in hair follicle stem cells using a novel mouse model with targeted overexpression of this receptor. The findings revealed significant dysregulation in hair follicle morphogenesis, with mutant mice showing increased numbers of hair follicles with altered morphology and localization. These follicles exhibited elevated proliferative activity and a higher prevalence of CD34 and ITGA6 positive stem cells. Additionally, the overexpression of ALK2 was found to attenuate cutaneous wound healing, indicating that hair follicle-specific ALK2 played a crucial role in maintaining the stem cell niche and influencing wound healing processes.
