Hair Follicle Specific ACVR1/ALK2 Critically Affects Skin Morphogenesis and Attenuates Wound Healing

May 2017 in “ Wound Repair and Regeneration ”

Michael Sorkin, Shailesh Agarwal, Kavitha Ranganathan, Shawn Loder, David Cholok, David Fireman, John Li, Shuli Li, Bin Zhao, Yuji Mishina, Paul S. Cederna, Benjamin Lévi

ACVR1 ALK2 BMP receptor hair follicle stem cells CD34 ITGA6 hair follicle morphogenesis cutaneous wound healing stem cell niche

TLDR Overexpression of ALK2 in hair follicles disrupts skin development and slows wound healing.

The study investigated the role of the BMP receptor ALK2/ACVR1 in hair follicle stem cells using a novel mouse model with targeted overexpression of this receptor. The findings revealed significant dysregulation in hair follicle morphogenesis, with mutant mice showing increased numbers of hair follicles with altered morphology and localization. These follicles exhibited elevated proliferative activity and a higher prevalence of CD34 and ITGA6 positive stem cells. Additionally, the overexpression of ALK2 was found to attenuate cutaneous wound healing, indicating that hair follicle-specific ALK2 played a crucial role in maintaining the stem cell niche and influencing wound healing processes.

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