Lnc056 Enhances Hair Follicle Stem Cells Proliferation by Binding Transcription Factor HNRNPUL1 to Up-Regulate TRIP6 Expression
June 2025
in “
PubMed
”
Studysummary This study found that the long non-coding RNA lnc056 promotes the proliferation of hair follicle stem cells by upregulating TRIP6 expression through interaction with the transcription factor HNRNPUL1, suggesting a potential target for hair loss treatment.
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This study investigates the role of the long non-coding RNA lnc056 in the proliferation of hair follicle stem cells (HFSCs). The research found that lnc056 is expressed in the nuclei of HFSCs and promotes their proliferation by up-regulating the expression of TRIP6 through binding with the transcription factor HNRNPUL1. The study utilized various methods, including RT-qPCR and overexpression assays, to demonstrate that lnc056 enhances HFSC proliferation via the HNRNPUL1/TRIP6 axis. These findings contribute to understanding the molecular mechanisms of lncRNA in the hair follicle cycle and suggest lnc056 as a potential therapeutic target for hair loss.
