Lnc056 Enhances Hair Follicle Stem Cells Proliferation by Binding Transcription Factor HNRNPUL1 to Up-Regulate TRIP6 Expression

This study investigates the role of the long non-coding RNA lnc056 in the proliferation of hair follicle stem cells (HFSCs). The research found that lnc056 is expressed in the nuclei of HFSCs and promotes their proliferation by up-regulating the expression of TRIP6 through binding with the transcription factor HNRNPUL1. The study utilized various methods, including RT-qPCR and overexpression assays, to demonstrate that lnc056 enhances HFSC proliferation via the HNRNPUL1/TRIP6 axis. These findings contribute to understanding the molecular mechanisms of lncRNA in the hair follicle cycle and suggest lnc056 as a potential therapeutic target for hair loss.