Diagnosis and Treatment of Nonscarring Hair Loss in Primary Care in 2021

    March 2021 in “ JAMA
    Paradi Mirmirani, Jennifer Fu
    Image of study
    TLDR Primary care in 2021 focused on identifying nonscarring hair loss and managing common types based on the pattern of hair loss.
    In 2021, the initial step in diagnosing hair loss (alopecia) was to distinguish between nonscarring and scarring alopecia. This review focused on nonscarring alopecia, the most common type of hair loss seen in primary care. Scarring alopecia, which permanently destroys follicular structures, was identified by symptoms such as itching, pain, redness, scaling, crust, and obliteration of follicular pore markings, resulting in an unusually smooth skin appearance. These patients might have needed a scalp biopsy for diagnosis and referral for specialized care. Once hair loss was classified as nonscarring, the next step was to identify the distribution of loss on the scalp as patterned, diffuse, or focal. The diagnosis and management of the most prevalent nonscarring disorders in each of these categories were discussed.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 21 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  121 upvotes 2 weeks ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Am I missing something with pp405?

      in Research/Science  32 upvotes 10 months ago
      PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

    Related Research

    3 / 3 results