LncRNA-miRNA-mRNA Regulatory Networks in Skin Aging and Therapeutic Potentials
October 2023
in “
Frontiers in physiology
”
skin aging wound healing ceRNAs miRNA RP11-670E13.6 miR-663a CDK4 CD6 UVB-induced senescence Meg3 miR-93-5p epiregulin UVB-induced inflammation H19 miR-296-5p IGF2 dermal fibroblast senescence MALAT1 miR-124 Wnt/β-catenin pathway hair follicle MSCs pyroptosis microRNA UVB-induced skin aging UVB-induced skin inflammation insulin-like growth factor 2 hair follicle mesenchymal stem cells
TLDR ceRNA networks offer potential treatments for skin aging and wound healing.
Skin aging is influenced by intrinsic and extrinsic factors, with molecular mechanisms still being explored. Competing endogenous RNAs (ceRNAs) regulate gene expression through miRNA competition, impacting skin aging and wound healing. Key findings include RP11-670E13.6-miR-663a-CDK4/CD6 delaying UVB-induced senescence, Meg3-miR-93-5p-epiregulin contributing to UVB-induced inflammation, and H19-miR-296-5p-IGF2 regulating dermal fibroblast senescence. In wound healing, MALAT1-miR-124 activates the Wnt/β-catenin pathway, and H19 from hair follicle MSCs inhibits pyroptosis. These ceRNA networks offer insights and potential therapeutic strategies for skin aging and wound healing, providing a foundation for future research in dermatology.
