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Glossarycompeting endogenous RNA (ceRNA)

molecules that regulate gene expression by sequestering microRNAs

Competing endogenous RNAs (ceRNAs) are molecules within cells that can regulate gene expression by "competing" for shared microRNAs. Essentially, they act like sponges, binding to microRNAs and preventing these microRNAs from attaching to their usual target messenger RNAs (mRNAs), which would otherwise inhibit the production of certain proteins. This mechanism plays a crucial role in various biological processes and diseases, including cancer and hair loss conditions like alopecia.

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research Synchronous Profiling and Analysis of mRNAs and ncRNAs in the Dermal Papilla Cells from Cashmere Goats

17 citations, June 2019 in “BMC genomics”

Non-coding RNAs help control hair growth in cashmere goats.

research LncRNA-miRNA-mRNA Regulatory Networks in Skin Aging and Therapeutic Potentials

3 citations, October 2023 in “Frontiers in physiology”

ceRNA networks offer potential treatments for skin aging and wound healing.

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

35 citations, May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

research The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

3 citations, February 2022 in “Frontiers in cell and developmental biology”

A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.

research Control by a Hair’s Breadth: The Role of MicroRNAs in the Skin

41 citations, September 2012 in “Cellular and Molecular Life Sciences”

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

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