Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

    February 2023 in “ Aging ”
    Hongliang Yang, Yan Zhang, Zhenwu Du, Tengfei Wu, Chun Yang
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    TLDR A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.
    The document details a study on the effects of exosomes containing lncRNA H19 from hair follicle mesenchymal stem cells (HF-MSCs) on diabetic skin wound healing. The study demonstrated that exosomal H19 promotes cell proliferation and migration, and inhibits pyroptosis by counteracting the NLRP3 inflammasome activation. In diabetic mice, wounds treated with exosomes overexpressing H19 healed more effectively compared to those treated with exosomes with suppressed H19 expression. The findings suggest that HF-MSC-derived exosomes overexpressing H19 could be a promising approach for treating diabetic skin wounds. However, the summary does not provide the number of mice or cells used in the study.
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