Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing
February 2023
in “
Aging
”
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Studysummary This study found that exosomes from hair follicle mesenchymal stem cells overexpressing lncRNA H19 promoted diabetic skin wound healing by enhancing cell proliferation, migration, and reducing pyroptosis.
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The document details a study on the effects of exosomes containing lncRNA H19 from hair follicle mesenchymal stem cells (HF-MSCs) on diabetic skin wound healing. The study demonstrated that exosomal H19 promotes cell proliferation and migration, and inhibits pyroptosis by counteracting the NLRP3 inflammasome activation. In diabetic mice, wounds treated with exosomes overexpressing H19 healed more effectively compared to those treated with exosomes with suppressed H19 expression. The findings suggest that HF-MSC-derived exosomes overexpressing H19 could be a promising approach for treating diabetic skin wounds. However, the summary does not provide the number of mice or cells used in the study.
