Junb Affects Hair Follicle Development And Regeneration By Promoting The Proliferation Of Dermal Papilla Cells In Goats

November 2023 in “ Chemical and Biological Technologies in Agriculture ”

Tongtong Zhang, Fang Li, Xiang Li, Xiongbo Zhou, Yujie Zheng, Xin Wang

JUNB hair follicle development hair regeneration dermal papilla cells TCF3 Wnt signaling pathway CTNNB1 β-catenin Cyclin D1 C-myc Wnt pathway beta-catenin

Studysummary This study found that JUNB enhances hair regeneration in mice by promoting dermal papilla cell proliferation through the Wnt signaling pathway, suggesting JUNB as a potential molecular target for improving cashmere quality and breeding in cashmere goats.

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The study explores the role of the transcription factor JUNB in hair follicle development and regeneration in cashmere goats, highlighting its impact on dermal papilla (DP) cells. JUNB was found to enhance the viability and proliferation of DP cells by activating the Wnt signaling pathway and increasing the expression of genes such as CTNNB1, Cyclin D1, and C-myc. In vivo experiments with C57 BL/6 mice confirmed that JUNB promotes hair regeneration. These results suggest that JUNB could be a molecular target for improving cashmere quality and breeding in goats.

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