Junb Affects Hair Follicle Development And Regeneration By Promoting The Proliferation Of Dermal Papilla Cells In Goats

The study investigates the role of the transcription factor JUNB in hair follicle development and regeneration, focusing on its effects on dermal papilla (DP) cells in cashmere goats. JUNB was found to significantly enhance the viability and proliferation of DP cells. The research identified TCF3 as a target gene of JUNB and demonstrated that JUNB upregulates genes related to the Wnt signaling pathway, such as CTNNB1 (β-catenin), Cyclin D1, and C-myc, at both mRNA and protein levels. High homology between goat and mouse JUNB protein sequences led to the use of C57 BL/6 mice for in vivo experiments, which confirmed that JUNB promotes hair regeneration. These findings suggest that JUNB could be a molecular target for improving cashmere quality and breeding in cashmere goats by enhancing hair regeneration through the Wnt signaling pathway.