ROR2 Regulates Self-Renewal and Maintenance of Hair Follicle Stem Cells

August 2022 in “ Nature Communications ”

Anthony Veltri, Christopher Lang, Gaia Cangiotti, Chim Kei Chan, Wen‐Hui Lien

ROR2 Wnt receptor hair follicle stem cells HFSCs Wnt-activated signaling ATM/ATR-dependent DNA damage response ROR2-PKC signaling β-catenin

TLDR ROR2 is essential for hair follicle stem cell renewal and maintenance.

This study investigated the role of ROR2, a Wnt receptor, in hair follicle stem cells (HFSCs). It was found that ROR2 was crucial for regulating Wnt-activated signaling, which is responsible for HFSC activation and self-renewal. Additionally, ROR2 was necessary for maintaining the ATM/ATR-dependent DNA damage response, essential for the long-term maintenance of HFSCs. The study also identified a compensatory role of ROR2-PKC signaling in protecting β-catenin-null HFSCs from losing their stem cell pool. Overall, the research revealed a previously unrecognized role of ROR2 in the regulation of stem cell self-renewal and maintenance.

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