Comprehensive Transcriptome Analysis of Hair Follicle Morphogenesis Reveals That lncRNA-H19 Promotes Dermal Papilla Cell Proliferation Through the Chi-miR-214-3p/Beta-Catenin Axis in Cashmere Goats

This study explores the role of lncRNA-H19 in hair follicle morphogenesis in cashmere goats, revealing that H19 promotes dermal papilla (DP) cell proliferation through the chi-miR-214-3p/β-catenin axis. Researchers identified 10,485 lncRNAs, 40,639 mRNAs, and 605 miRNAs during different HF development stages. H19 increases β-catenin levels and upregulates Wnt pathway factors, enhancing DP cell proliferation by acting as a competing endogenous RNA (ceRNA) for chi-miR-214-3p, which inhibits DP cell proliferation by targeting β-catenin. The study highlights the importance of lncRNAs and miRNAs in HF development and suggests H19 as a potential marker for improving cashmere yield and quality through molecular breeding.