Melatonin Regulates the Mitogen-Activated Protein Kinase Pathway via the CircMPP5-miR-211-MAPK3 Axis to Induce Secondary Hair Follicle Differentiation and Development in Newborn Cashmere Goat Kids

    October 2022 in “ Research Square (Research Square) ”
    Xiaogao Diao, Lingyun Yao, Tao Duan, Jiaxin Qin, Liwen He, Wei Zhang
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    TLDR Melatonin helps improve Cashmere goat hair quality by promoting hair follicle growth through a specific cell signaling pathway.
    The study found that melatonin (MT) treatment in newborn Cashmere goat kids can increase the density of secondary hair follicles, thereby improving the yield and quality of Cashmere. This improvement is due to increased antioxidant levels, expression of anti-apoptotic protein, and reduced apoptosis. The study also discovered that MT promotes the proliferation of secondary hair follicle cells at an early age. The genome-wide data analysis revealed that the MAPK signaling pathway, with key genes (FGF2, FGF21, FGFR3, MAPK3 (ERK1)) being up-regulated and expressed, is involved in the development of secondary hair follicles. The study concluded that MT regulates the MAPK pathway through the circMPP5-miR-211-MAPK3 axis to induce the differentiation and proliferation of secondary hair follicle cells, leading to increased numbers of secondary hair follicles and improved Cashmere production.
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