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research Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

475 citations , October 2006 in “Proceedings of the National Academy of Sciences”

This study suggests that folliculin, mutated in Birt–Hogg–Dubé syndrome, and its partner FNIP1 may play a role in energy and nutrient sensing through the AMPK and mTOR pathways.

research The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

207 citations , July 2006 in “Development”

This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.

research Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1

75 citations , February 2017 in “Aging”

This study found that treating mtDNA mutator mice with the antioxidant SkQ1 delayed aging traits and extended their lifespan, potentially by alleviating mitochondrial dysfunction caused by reactive oxygen species.

research Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin

74 citations , October 2015 in “Experimental Dermatology”

This study found that mTOR gene expression was significantly increased and S6K1 activation was observed in skin samples from acne patients compared to healthy controls, suggesting mTORC1's involvement in acne pathogenesis.

research mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration

71 citations , January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

This study found that mTOR signaling plays a crucial role in activating hair follicle stem cells by balancing BMP-mediated repression, essential for hair regeneration.

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Community Join

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community (MTF 35) 20 Months Feminizing HRT

in Transgender 18 upvotes 7 months ago

A 35-year-old transgender woman experienced hair regrowth with feminizing HRT, adding dutasteride and bicalutamide, and plans a hair transplant for further improvement. Estrogen also improved skin appearance, and the user advises against cisgender men using feminizing HRT for hair regrowth.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 8 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

community MTF why am I suddenly shedding hair of exactly the same length

4 upvotes 4 years ago

The user experienced hair shedding after increasing minoxidil from 5% to 7% with latanoprost, possibly causing telogen effluvium. They are on HRT with Lupron, Estradiol, and Raloxifene, and are concerned about the shedding's duration.

community 34 MtF Hair progress timeline pics

38 upvotes 1 month ago

A 34-year-old MtF individual shared their hair regrowth journey using finasteride, minoxidil, estrogen, cyproterone acetate, and dutasteride, noting positive progress despite some setbacks. They experienced side effects like anxiety from cyproterone acetate and desired effects from estrogen, such as feminine fat distribution.

community ~6 mths on Fin, time to give up?

in Finasteride/Dutasteride 13 upvotes 1 month ago

The user is considering giving up on finasteride after 6 months due to lack of noticeable hair growth, but others suggest adding minoxidil and being patient as improvements can take longer. Many recommend continuing treatment and possibly adding minoxidil for better results.

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Clinics

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Learn

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learn Hair Transplant

How many grafts do I need for a receding hairline in a hair transplant? You typically need 800 to 2,500 grafts for a receding hairline.
What results can I expect from a hair transplant? Expect new hair growth in 3-4 months, with full results in 9-12 months.
How much does a hair transplant cost? Hair transplant costs typically range from $1,000 to $25,000 depending on various factors.
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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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