Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

The study investigated the role of the epidermal E-cadherin dependent β-catenin pathway in hair growth, finding that it could be activated by phytochemicals like tocotrienol-rich fraction (TRF), leading to accelerated anagen hair cycling. TRF application in both healthy and diabetic mice downregulated E-cadherin, increased β-catenin, and promoted its nuclear translocation, which interacted with Tcf3 to induce pluripotency factors. The β-catenin inhibitor IWR-1 impaired this effect, underscoring the pathway's importance in hair follicle regeneration. The findings suggested that targeting this pathway could be a promising strategy for treating hair loss conditions.