Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

    July 2017 in “ Molecular therapy ”
    Noha Ahmed, Subhadip Ghatak, Mohamed El Masry, Surya Gnyawali, Sashwati Roy, Mona G. Amer, Helen B. Everts, Chandan K. Sen, Savita Khanna
    TLDR A form of vitamin E promotes hair growth by activating a specific skin pathway.
    The study investigated the role of the epidermal E-cadherin dependent β-catenin pathway in hair growth, finding that it could be activated by phytochemicals like tocotrienol-rich fraction (TRF), leading to accelerated anagen hair cycling. TRF application in both healthy and diabetic mice downregulated E-cadherin, increased β-catenin, and promoted its nuclear translocation, which interacted with Tcf3 to induce pluripotency factors. The β-catenin inhibitor IWR-1 impaired this effect, underscoring the pathway's importance in hair follicle regeneration. The findings suggested that targeting this pathway could be a promising strategy for treating hair loss conditions.
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      community Interesting anecdote regarding TOPICAL vitamin e

      in Research/Science  23 upvotes 1 year ago
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      community We don't talk about vitamin E enough

       60 upvotes 5 years ago
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