Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

July 2017 in “ Molecular therapy ”

Noha Ahmed, Subhadip Ghatak, Mohamed El Masry, Surya Gnyawali, Sashwati Roy, Mona G. Amer, Helen B. Everts, Chandan K. Sen, Savita Khanna

E-cadherin β-catenin tocotrienol-rich fraction TRF anagen hair cycling IWR-1 hair follicle regeneration Tcf3 pluripotency factors anagen phase hair growth

TLDR A form of vitamin E promotes hair growth by activating a specific skin pathway.

The study investigated the role of the epidermal E-cadherin dependent β-catenin pathway in hair growth, finding that it could be activated by phytochemicals like tocotrienol-rich fraction (TRF), leading to accelerated anagen hair cycling. TRF application in both healthy and diabetic mice downregulated E-cadherin, increased β-catenin, and promoted its nuclear translocation, which interacted with Tcf3 to induce pluripotency factors. The β-catenin inhibitor IWR-1 impaired this effect, underscoring the pathway's importance in hair follicle regeneration. The findings suggested that targeting this pathway could be a promising strategy for treating hair loss conditions.

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Research cited in this study

19 / 19 results

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The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

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Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

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Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

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Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.

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Tocotrienol supplements significantly increased hair growth in people with hair loss.

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Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

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