Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

    July 2017 in “ Molecular therapy
    Noha Ahmed, Subhadip Ghatak, Mohamed El Masry, Surya Gnyawali, Sashwati Roy, Mona G. Amer, Helen B. Everts, Chandan K. Sen, Savita Khanna
    TLDR A form of vitamin E promotes hair growth by activating a specific skin pathway.
    The study investigated the role of the epidermal E-cadherin dependent β-catenin pathway in hair growth, finding that it could be activated by phytochemicals like tocotrienol-rich fraction (TRF), leading to accelerated anagen hair cycling. TRF application in both healthy and diabetic mice downregulated E-cadherin, increased β-catenin, and promoted its nuclear translocation, which interacted with Tcf3 to induce pluripotency factors. The β-catenin inhibitor IWR-1 impaired this effect, underscoring the pathway's importance in hair follicle regeneration. The findings suggested that targeting this pathway could be a promising strategy for treating hair loss conditions.
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       20 upvotes 5 years ago
      Vitamin E was discussed as a treatment for hair shedding, with a specific form mentioned. A user shared a link to a study and started taking the Vitamin E variants used.

      community Interesting anecdote regarding TOPICAL vitamin e

      in Research/Science  23 upvotes 1 year ago
      A user accidentally discovered that applying vitamin E oil to their scalp significantly reduced their hair shedding for about 1.5 weeks. They reported improved hair quality and a drastic decrease in hair loss after treatment.

      community We don't talk about vitamin E enough

       60 upvotes 5 years ago
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