Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Cashmere Follicle Transition in Cashmere Goats

June 2020 in “ BMC genomics ”

Feng Yang, Zhihong Liu, Meng Zhao, Qing Mu, Tianyu Che, Yingxin Xie, Lina Ma, Lu Mi, Jinquan Li, Yunlong Zhao

skin transcriptome gene expression cashmere follicles KAP3-1 KRTAP 8-1 KRTAP 24-1 hair growth hair shedding hair follicle biology

TLDR The study identified key genes that regulate the growth cycle of cashmere in goats, which could help improve breeding strategies.

The study investigated the periodic changes in gene expression associated with the transition of cashmere (ground hair) follicles in Inner Mongolian cashmere goats. By analyzing the skin transcriptome and using quantitative reverse transcription PCR, researchers identified key genes such as KAP3-1, KRTAP 8-1, and KRTAP 24-1, which showed significant fluctuations in expression throughout the year, particularly during the growth phase (March–September). These findings provided insights into the molecular mechanisms regulating hair growth and shedding, contributing to a better understanding of hair follicle biology and offering a theoretical foundation for improving cashmere production through targeted breeding strategies.

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research The Inconsistent Regulation of HOXC13 on Different Keratins and the Regulation Mechanism on HOXC13 in Cashmere Goat (Capra Hircus)

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research Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

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research Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns

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research Unraveling the Secret Life of the Hair Follicle: From Fungi to Innovative Hair Loss Therapies

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research The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family

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research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

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research Skin Keratins

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research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

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research Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration

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research Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle

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research Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments

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research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

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research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

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research Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen

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research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

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research Genetic Basis of Skin Appendage Development

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research Scratching the Surface of Skin Development

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research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

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research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1

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research Molecular Mechanisms Regulating Hair Follicle Development

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research HKAP1.6 And HKAP1.7, Two Novel Human High Sulfur Keratin-Associated Proteins Are Expressed In The Hair Follicle Cortex

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3 / 3 results

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research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)

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