Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns

    June 2017 in “ Developmental Biology ”
    Maureen Cetera, Liliya Leybova, Frank W. Woo … Danelle Devenport
    Studysummary This study found that local refinement of hair follicles into higher order patterns can occur without the core planar cell polarity system, but global alignment with body axes requires its function throughout development and regeneration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on europepmc.org →
    Discuss this study in the Community →

    Research cited in this study 10

    1. Frizzled Receptors in Development and Disease Current topics in developmental biology/Current Topics in Developmental Biology · 2016
    2. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    3. Partial Interchangeability of Fz3 and Fz6 in Tissue Polarity Signaling for Epithelial Orientation and Axon Growth and Guidance Development · 2014
    4. Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology Journal of Visualized Experiments · 2014
    5. Responses of Hair Follicle–Associated Structures to Loss of Planar Cell Polarity Signaling Proceedings of the National Academy of Sciences of the United States of America · 2013
    6. When Whorls Collide: The Development of Hair Patterns in Frizzled 6 Mutant Mice Development · 2010
    7. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009
    8. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    9. Order From Disorder: Self-Organization In Mammalian Hair Patterning Proceedings of the National Academy of Sciences · 2006
    10. The Hair Cycle Journal of Cell Science · 2006

    Related research 4

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    3. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    4. Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle Journal of Investigative Dermatology · 1994